Application of drying equipment in the pharmaceutical industry

China Drying News With the rapid development of society, people are demanding more and more drugs. Although Western European countries have advanced technology and equipment, due to their high requirements for environmental protection and high wages of the labor force, the high operating costs make it difficult for these countries to maintain the continuous production of APIs and intermediates. Gradually form the trend of foreign pharmaceutical companies investing and setting up factories in developing countries. Undoubtedly, China is an ideal country to invest in, with sufficient manpower and material resources. In recent years, China's pharmaceutical industry has made considerable progress.

GMP's drug regulations expressly state that all pharmaceutical equipment must comply with GMP production requirements and must be capable of in-situ cleaning and in-situ sterilization. During the operation of the equipment, there must be no secondary pollution to the medicine. To address this requirement, we use a positive pressure drying process for low-energy aseptic spray drying equipment. 0.5u of dust particles in the hot air entering the tower does not exceed 10/liter. Operating temperature can be 0--150 °C, using a three-fluid nozzle. The vapor-liquid contact is good and the atomization is even, which meets the aseptic operation requirements. Due to the good contact of the mist and the short drying time, the dry strength can reach about 7 kg (water)/m3•hour.

In order to better reduce costs, increase production efficiency, and reduce the labor intensity of workers in the pharmaceutical process, according to foreign technical data, in 2000 it developed its own filtration, washing, and drying "triple play" equipment. The equipment can complete filtration, washing (bleeding), and drying in a sealed container. At the same time, it replaces filtration and drying equipment . It can achieve continuous operation in the whole closed and full process, and is more suitable for products requiring asepsis. The production of toxic products.

In the filtration stage, the crystal and the mother liquor are separated and operated under pressurized vacuum conditions. The smoothing and compaction of the filter cake through the smoothing of the S-type stirring paddles makes the solid-liquid separation effect better. A special rotating spray device is arranged in the container so that the cleaning liquid is evenly distributed in the container. The internal cleaning of the container and the cleaning of the material can be achieved. Through the rotation and lifting of the stirring blades, the filter cake and the cleaning liquid are mixed more uniformly. The slurry cake was thoroughly washed. The filter cake after suction filtration is scraped and heated by the stirring slurry layer by layer to heat the entire barrel body, the chassis, and the blade to scrape the material. The side discharge device is opened, and the material is automatically discharged from the discharge port on the side of the tank wall through the pushing of the blade.

In order to reduce the investment of equipment and equipment processes in the processing of pharmaceuticals, the company has developed a “five-in-one” device based on double cones, ie, five processes of crystallization, reaction, filtration, washing, and drying in a single device. . One end of the double cone is designed as a circular arc bottom and a stirring blade is designed. In the reaction and crystallization, the cone faces downward, and uniform crystallization and reaction are achieved by stirring the stirring leaves. After crystallization, reaction, the cone was rotated 180°C. At one end of the cone is designed a filter sintered mesh device. After the suction filter is connected, the mother liquor is filtered and the washing solution is passed through the washing interface. The filter cake is washed during the revolving process. After the washing process is completed, as in the double-cone drying process, in order to prevent the material from pilling, the stir-leaf can also be used to start smashing the material. After drying, open the end cap discharge (same double cone) and clean the material at one time. Therefore, this kind of equipment is more practical and combines the advantages of the tank type three-in-one and double-cone.

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